Publications Citing the use of
Strex Cell Stretching Systems and Chambers

Cell adhesion

Poly (N-isopropylacrylamide) grafted PDMS substrate for controlling cell adhesion and detachment by dual stimulation of temperature and mechanical stress.
Akiyama, Y., Matsuyama, M., Yamato, M., Takeda, N., & Okano, T.
(2018). Biomacromolecules.

N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes.
Matsuda, T., Takahashi, K., Nariai, T., Ito, T., Takatani, T., Fujio, Y., & Azuma, J.
(2004). Biochemical and biophysical research communications, 326(1), 228-232.

Gene Expression

Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells.
Suzuki, M., Takahashi, N., Sobue, Y., Ohashi, Y., Kishimoto, K., Hattori, K., … & Kojima, T.
(2020).  Scientific Reports10(1), 1-9.

Functions of beta2‐adrenergic receptor in human periodontal ligament cells.
Hamano, S., Tomokiyo, A., Hasegawa, D., Yuda, A., Sugii, H., Yoshida, S., … & Maeda, H.
Journal of Cellular Biochemistry.

Mechanotransduction Studies

Differences between the root and horn cells of the human medial meniscus from the osteoarthritic knee in cellular characteristics and responses to mechanical stress.
Okazaki, Y., Furumatsu, T., Kamatsuki, Y., Nishida, K., Nasu, Y., Nakahara, R., … & Ozaki, T.
(2020).  Journal of Orthopaedic Science.

Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis.
Kinoshita, N., Hashimoto, Y., Yasue, N., Suzuki, M., Cristea, I. M., & Ueno, N.
(2020).  Cell Reports30(11), 3875-3888.

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.
Xuan, F., Yano, F., Mori, D., Chijimatsu, R., Maenohara, Y., Nakamoto, H., … & Hojo, H.
(2019).  Arthritis Research & Therapy21(1), 1-11.

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology. 
Doryab, A., Tas, S., Taskin, M. B., Yang, L., Hilgendorff, A., Groll, J., … & Schmid, O.
Advanced Functional Materials, 1903114.

Stretch in Focus: 2D Inplane Cell Stretch Systems for Studies of Cardiac Mechano-Signaling.
Friedrich O, Merten A-L, Schneidereit D, Guo Y, Schürmann S and Martinac B.
(2019) Front. Bioeng. Biotechnol. 7:55. doi: 10.3389/fbioe.2019.00055

Impaired vascular smooth muscle cell force-generating capacity and phenotypic deregulation in Marfan Syndrome mice.
Nolasco, P., Fernandes, C. G., Ribeiro-Silva, J. C., Oliveira, P. V., Sacrini, M., de Brito, I. V., … & Laurindo, F. R. M.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 165587.

Depletion of glycosphingolipids induces excessive response of chondrocytes under mechanical stress.
Matsubara, S., Onodera, T., Maeda, E., Momma, D., Matsuoka, M., Homan, K., … & Iwasaki, N.
(2019).  Journal of Biomechanics.

Bone and cartilage tissue engineering for growth modification using bone marrow derived mesenchymal stem cells (BMMSCs) on a resorbable electro-spun scaffold.
Souaid R., Macari A., Ghafari J., Sabban M.
(2019) American University of Beirut, Department of Orthodontics and Dentofacial Orthopedics, Program and Division of Anatomy, Cell Biology and Phsyiology, American University of Beirut, Beirut, Lebanon.

Responses of bladder smooth muscle to the stretch go through extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/Nuclear factor‐κB (NF‐κB) Pathway.
Li, Y., He, M., Lin, W., Xiang, Z., Huang, J., Xu, P., … & Wang, H.
Neurourology and urodynamics.

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway.
Chang, S. H., Mori, D., Kobayashi, H., Mori, Y., Nakamoto, H., Okada, K., … & Kim-Kaneyama, J. R.
Nature Communications10(1), 1442.

p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Yamada, M., Iwata, M., Warabi, E., Oishi, H., Lira, V. A., & Okutsu, M.
(2019) The FASEB Journal, fj-201900133R.

Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation.
Koseki, H., Miyata, H., Shimo, S., Ohno, N., Mifune, K., Shimano, K., … & Aoki, T.
(2019) Translational Stroke Research, 1-13.

Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies.
Li, M., Zhang, C., & Yang, Y.
(2019) Bone & Joint Research, 8(1), 19-31.

MT1‐MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching‐inhibited invasion of bone‐marrow‐derived mesenchymal stem cells.
Fu, X., Halim, A., Tian, B., Luo, Q., & Song, G.
(2019)  Journal of cellular physiology.

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas.
Shimizu, T., Osanai, Y., Tanaka, K. F., Thai, T. Q., Abe, M., Natsume, R., … & Ikenaka, K.
(2018) Journal of Neurochemistry.

TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons.
Katanosaka, K., Takatsu, S., Mizumura, K., Naruse, K., & Katanosaka, Y.
(2018) Scientific reports, 8(1), 16782.

R‐spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β‐catenin signaling pathway.
Arima, M., Hasegawa, D., Yoshida, S., Mitarai, H., Tomokiyo, A., Hamano, S., … & Maeda, H.
(2018) Journal of periodontal research.

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells.
Nakajima, T., Shibata, M., Nishio, M., Nagata, S., Alev, C., Sakurai, H., … & Ikeya, M.
(2018) Development, 145(16), dev165431.

Localization of leucine-rich repeat-containing G-protein-coupled receptor 5-and Ki67-positive periodontal cells expressing runt-related transcription factor 2 during tooth movement.
Hosomichi, J., Shibutani, N., Yamaguchi, H., Hatano, K., Kuma, Y., Suzuki, T., … & Ono, T.
(2018) Orthodontic Waves.

Effects of Daidzein on the Production of Type I Collagen and Matrix Metalloproteinase1 by Stretched Human Periodontal Ligament Cells.
Yamaguchi, M., Nakayama, E., Shimizu, M., Kikuta, J., Horihata, S., & Kasai, K.
(2018) International Journal of Oral-Medical Sciences, 17(1), 27-32.

Cyclic Stretching Exacerbates Tendinitis by Enhancing NLRP3 Inflammasome Activity via F-Actin Depolymerization.
Chen, Q., Zhou, J., Zhang, B., Chen, Z., Luo, Q., & Song, G.
(2018) Inflammation, 1-13.

Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.
Pandey, D., Nomura, Y., Rossberg, M. C., Hori, D., Bhatta, A., Keceli, G., … & Romer, L.
Arteriosclerosis, thrombosis, and vascular biology, ATVBAHA-117.

MECHANOMEDICINE: applications of mechanobiology to medical sciences and next-generation medical technologies.
(2018). Journal of Smooth Muscle Research, 54, 83-90.

Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts.
Takahashi, K., Ito, S., Furuya, K., Asano, S., Sokabe, M., & Hasegawa, Y.
Respiratory Physiology & Neurobiology.

P2Y 6-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice.
Kira, S., Yoshiyama, M., Tsuchiya, S., Shigetomi, E., Miyamoto, T., Nakagomi, H., … & Koizumi, S.,
Scientific Reports, 7(1), 771.

Contribution of plasma membrane lipid domains to red blood cell (re) shaping.
Léonard, C., Conrard, L., Guthmann, M., Pollet, H., Carquin, M., Vermylen, C., … & Tyteca, D.
(2017). Scientific reports, 7(1), 4264.

Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes.
Machida, T., Nishida, K., Nasu, Y., Nakahara, R., Ozawa, M., Harada, R., … & Ozaki, T.
Inflammation Research, 1-11.

Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts.
Takahashi, K., Ito, S., Furuya, K., Asano, S., Sokabe, M., & Hasegawa, Y.
Respiratory Physiology & Neurobiology.

AB0072 Hyaluronan inhibition of mechanical stress-induced protease expressions by human chondrocytes.
M. Ozawa, K. Nishida, K. Hashizume, R. Nakahara, T. Saito, T. Kanazawa, R. Harada, T. Machida, T. Ozaki,
Abstracts accepted for publication: Cartilage, synovium and osteoimmunology

Evaluation of Precise Optimal Cyclic Strain for Tenogenic Differentiation of MSCs.
Morita, Y., Sato, T., Watanabe, S., & Ju, Y.
(2016).  In Mechanics of Biological Systems and Materials, Volume 6 (pp. 149-155). Springer International Publishing.

Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase.
Nakagomi, H., Yoshiyama, M., Mochizuki, T., Miyamoto, T., Komatsu, R., Imura, Y., … & Araki, I.
(2016). Scientific Reports, 6, 29761.

Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs.
Takeda, H., Komori, K., Nishikimi, N., Nimura, Y., Sokabe, M., & Naruse, K.
(2006). Life sciences, 79(3), 233-239.

N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes.
Matsuda, T., Fujio, Y., Nariai, T., Ito, T., Yamane, M., Takatani, T., … & Azuma, J.
(2006). Journal of molecular and cellular cardiology, 40(4), 495-502

Mechanotransduction research driving soft lithography.
Naruse, K.
(2006). Protein, Nucleic Acid and Enzyme, 51, 705-714

Stretch-induced cell proliferation is mediated by FAK-MAPK pathway.
Wang, J. G., Miyazu, M., Xiang, P., Li, S. N., Sokabe, M., & Naruse, K.
(2005). Life sciences, 76(24), 2817-2825.

Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch.
Sasamoto, A., Nagino, M., Kobayashi, S., Naruse, K., Nimura, Y., & Sokabe, M.
(2005).  American Journal of Physiology-Cell Physiology, 288(5), C1012-C1022.

Involvement of reactive oxygen species in cyclic stretch‐induced NF‐κB activation in human fibroblast cells.
Amma, H., Naruse, K., Ishiguro, N., & Sokabe, M.
(2005). British journal of pharmacology, 145(3), 364-373.

Characteristics of subepithelial fibroblasts as a mechano-sensor in the intestine: cell-shape-dependent ATP release and P2Y1 signaling.
Furuya, K., Sokabe, M., & Furuya, S.
(2005). Journal of cell science, 118(15), 3289-3304.

Activation of a mechanosensitive BK channel by membrane stress created with amphipaths.
Qi, Z., Chi, S., Su, X., Naruse, K., & Sokabe, M.
(2005). Molecular membrane biology, 22(6), 519-527.

Soft lithography and mechanobiology.
Naruse, K.
(2004). Vascular Biology & Medicine, 5,237-244

Uni-axial cyclic stretch induces the activation of transcription factor nuclear factor κB in human fibroblast cells.
Inoh, H., Ishiguro, N., Sawazaki, S. I., Amma, H., Miyazu, M., Iwata, H., … & Naruse, K.
(2002). The FASEB Journal, 16(3), 405-407.

Molecular identification of a eukaryotic, stretch-activated nonselective cation channel.
Kanzaki, M., Nagasawa, M., Kojima, I., Sato, C., Naruse, K., Sokabe, M., & Iida, H.
(1999). Science, 285(5429), 882-886.

Orientation change of cardiocytes induced by cyclic stretch stimulation: time dependency and involvement of protein kinases.
Kada, K., Yasui, K., Naruse, K., Kamiya, K., Kodama, I., & Toyama, J.
(1999). Journal of molecular and cellular cardiology, 31(1), 247-259.

Activation of pp60 (src) is critical for stretch-induced orienting response in fibroblasts.
Sai, X., Naruse, K., & Sokabe, M.
(1999). Journal of cell science, 112(9), 1365-1373.

Up-regulation of COX2 expression by uni-axial cyclic stretch in human lung fibroblast cells.
Kato, T., Ishiguro, N., Iwata, H., Kojima, T., Ito, T., & Naruse, K
(1998). Biochemical and biophysical research communications, 244(3), 615-619.

Pp125^ F^ A^ K is required for stretch dependent morphological response of endothelial cells.
Naruse, K., Yamada, T., Sai, X. R., Hamaguchi, M., & Sokabe, M.
(1998). Oncogene, 17(4), 455-463.



Dynamic Contact Guidance of Myoblasts by Feature Size and Reversible Switching of Substrate Topography: Orchestration of Cell Shape, Orientation and Nematic Ordering of Actin Cytoskeletons.
Linke, P., Suzuki, R., Yamamoto, A., Nakahata, M., Kengaku, M., Fujiwara, T., … & Tanaka, M.
(2018).  Langmuir.

Fabrication of reconfigurable protein matrices by cracking.
Zhu, X., Mills, K. L., Peters, P. R., Bahng, J. H., Liu, E. H., Shim, J., … & Takayama, S.
(2005). Nature materials, 4(5), 403-406.

Stretch-activated channels

L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2.
Takahashi, K., Hayashi, S., Miyajima, M., Omori, M., Wang, J., Kaihara, K., … & Naruse, K.
(2019).Cell calcium.

The time‐dependent variation of ATP release in mouse primary‐cultured urothelial cells is regulated by the clock gene.
Ihara, T., Mitsui, T., Nakamura, Y., Kanda, M., Tsuchiya, S., Kira, S., … & Shinozaki, Y.
(2018). in Neurourology and urodynamics.

Observation of Calcium Wave on Physical Stimulus for Realizing Cell Tactile Sensor.
Kawashima, H., Sajnani, U., Shimizu, M., & Hosoda, K.
(2018) Conference on Biomimetic and Biohybrid Systems (pp. 255-262). Springer, Cham.

The oscillation of intracellular Ca 2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium.
Ihara, T., Mitsui, T., Nakamura, Y., Kanda, M., Tsuchiya, S., Kira, S., … & Shigetomi, E.
(2018) Scientific Reports, 8(1), 5699.

Leucine Supplementation After Mechanical Stimulation Activates Protein Synthesis via L‐type Amino Acid Transporter 1 In Vitro.
Nakai, N., Kawano, F., Murakami, T., Nakata, K., & Higashida, K.
(2017) Journal of Cellular Biochemistry.

P2Y 6-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice.
Kira, S., Yoshiyama, M., Tsuchiya, S., Shigetomi, E., Miyamoto, T., Nakagomi, H., … & Koizumi, S.,
Scientific Reports, 7(1), 771.

Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.
Ito, S., Kume, H., Oguma, T., Ito, Y., Kondo, M., Shimokata, K., … & Naruse, K.
(2006). European journal of pharmacology, 552(1), 135-142.

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts.
Danciu, T. E., Adam, R. M., Naruse, K., Freeman, M. R., & Hauschka, P. V.
(2003).FEBS letters, 536(1), 193-197.

Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch.
Naruse, K., Yamada, T., & Sokabe, M.
(1998). American Journal of Physiology-Heart and Circulatory Physiology, 274(5), H1532-H1538.

SA channel mediates superoxide production in HUVECs.
Aikawa, K., Nishikimi, N., Sakurai, T., Nimura, Y., Sokabe, M., & Naruse, K.
(2001). Life sciences, 69(15), 1717-1724.