Publications Citing the use of
Strex Cell Stretching Systems and Chambers

2026

Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect.
Berrueta, L., Bhan, C., He, Y., Thompson, R. D., Safairad, O., Doyle, A. D., … & Langevin, H. M.
(2026). b BMC biology.

2025

Membrane potential mediates the cellular response to mechanical pressure.
Mukherjee, A., Huang, Y., Elgeti, J., Oh, S., Abreu, J. G., Ammar, L., … & Basan, M.
(2025). Cell.

Mechanical stretch promotes the migration of mesenchymal stem cells via Piezo1/F-actin/YAP axis.
Ma, N., Huang, L., Zhou, Q., Zhang, X., Luo, Q., & Song, G.
(2025). Experimental Cell Research, 446(1), 114461.

Piezo1 promotes double-directional differentiation from human periodontal ligament progenitor cells.
Kono, Y., Kajiya, H., Nagano, R., Tominaga, C., Maeda, H., Fujita, T., & Tamaoki, S.
(2025). Journal of Oral Biosciences, 67(2), 100651.

In vitro mechanical stretch inhibits differentiation of mouse myoblast C2C12 cells without sustained eIF2α phosphorylation.
Mori, K., Asahi, T., Kataoka, K., & Akiyama, Y.
(2025). Biochemical and Biophysical Research Communications, 152350.

Piezo1-mediated mechanotransduction in cementocytes via protein kinase B and p38 mitogen-activated protein kinase signaling.
Xiong, K., Sakisaka, Y., Tenkumo, T., Nemoto, E., Maruyama, K., Muhammad, F., … & Yamada, S.
(2025). Journal of Dental Sciences.

ATR-hippo drives force signaling to nuclear F-actin and links mechanotransduction to neurological disorders.
Chatzifrangkeskou, M., Stanly, T., Koennig, D., Campos-Soares, L., Eyres, M., Hasson, A., … & O’Neill, E.
(2025). Science Advances, 11(7), eadr5683.

Transient ocular hypertension remodels astrocytes through S100B.
Huang, W., Matsushita, K., Kawashima, R., Hara, S., Yasukura, Y., Yamaguchi, K., … & Nishida, K.
(2025). PLOS ONE, 20(2), e0313556.

Signaling pathways of pro-IL-1β production induced by mechanical stress in gingival epithelial cells.
Zhang, R., Sougawa, N., Mao, D., Inoue, H., & Goda, S.
(2025). Journal of Oral Biosciences, 100626.

Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: linking mechanical stress to ocular inflammation.
Fukuoka, S., Adachi, N., Ouchi, E., Ikemoto, H., Okumo, T., Ishikawa, F., … & Sunagawa, M.
(2025). The Ocular Surface.

A comprehensive review of contemporary bioreactors for vascular inflammation studies.
Capalbo, S., Polyakova, A., El Imane, Z., Khan, I., Kawai, T., Shindo, S., & Salinas, M.
(2025). Inflammation, 1–36.

2024

Targeting the complexity of in vitro skin models: a review of cutting-edge developments.
Quílez, C., Bebiano, L. B., Jones, E., Maver, U., Meesters, L., Parzymies, P., … & Velasco, D.
(2024). Journal of Investigative Dermatology, 144(12), 2650–2670.

Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept.
Kamal, K. Y., Othman, M. A., Kim, J. H., & Lawler, J. M.
(2024). npj Microgravity, 10(1), 62.

Novel therapeutic strategy for intractable keloids: suppression of intracellular mechanotransduction and actin polymerisation via Rho-kinase pathway inhibition.
Min, S., Kim, K. M., Park, J. H., Lee, M., Hwang, J., & Park, J. U.
(2024). British Journal of Dermatology, ljae384.

Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells.
Maihemuti, W., Murata, K., Abulaiti, M., Minatoya, K., & Masumoto, H.
(2024). Biochemical and Biophysical Research Communications, 150605.

A comprehensive retrospective study on the mechanisms of cyclic mechanical stretch-induced vascular smooth muscle cell death underlying aortic dissection and potential therapeutics for preventing acute aortic aneurysm and associated ruptures.
Zhao, J., & Yoshizumi, M.
(2024). International Journal of Molecular Sciences, 25(5), 2544.

Inhibitory effect of a tankyrase inhibitor on mechanical stress-induced protease expression in human articular chondrocytes.
Hotta, Y., Nishida, K., Yoshida, A., Nasu, Y., Nakahara, R., Naniwa, S., … & Ozaki, T.
(2024). International Journal of Molecular Sciences, 25(3), 1443.

2023

Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy.
Ogino, S., Yoshikawa, K., Nagase, T., Mikami, K., & Nagase, M.
(2023). Hypertension Research, 1–13.

G protein-coupled receptor 55 activated by palmitoylethanolamide is associated with the development of nocturia associated with circadian rhythm disorders.
Ihara, T., Shinozaki, Y., Shigetomi, E., Danjo, Y., Tsuchiya, S., Kanda, M., … & Mitsui, T.
(2023). Life Sciences, 122072.

Altered actin dynamics is possibly implicated in the inhibition of mechanical stimulation‐induced dermal fibroblast differentiation into myofibroblasts.
Kuroda, K., Kiya, K., Matsuzaki, S., Takamura, H., Otani, N., Tomita, K., … & Kubo, T.
(2023). Experimental Dermatology.

Senso-immunology: the emerging connection between pain and immunity.
Maruyama, K.
(2023). The Keio Journal of Medicine, 2022-0037.

Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload.
Kishimoto, H., Iwasaki, M., Wada, K., Horitani, K., Tsukamoto, O., Kamikubo, K., … & Shiojima, I.
(2023). iScience.

Stretching promotes wound contraction through enhanced expression of endothelin receptor B and TRPC3 in fibroblasts.
Kawai, K., Ishise, H., Kubo, T., Larson, B., Fujiwara, T., Nishimoto, S., & Kakibuchi, M.
(2023). Plastic and Reconstructive Surgery Global Open, 11(4).

Aggravation of cellular senescence in human periodontal fibroblasts cultured with tobacco smoke components by stretching stimulation.
Zhao, M., Jo, J. I., Nishiura, A., Morikuni, H., Fujiwara, S. I., Honda, Y., & Matsumoto, N.
(2023). Journal of Osaka Dental University, 57(1), 47–53.

2022

Periodontal ligaments enhance neurite outgrowth in trigeminal ganglion neurons through Wnt5a production induced by mechanical stimulation.
Takahashi, K., Yoshida, T., & Wakamori, M.
(2022). American Journal of Physiology-Cell Physiology, 323(6), C1704–C1719.

TRPC1 channels underlie stretch-modulated sarcoplasmic reticulum calcium leak in cardiomyocytes.
Streiff, M. E., Corbin, A. C., Ahmad, A. A., Hunter, C., & Sachse, F. B.
(2022). Frontiers in Physiology, 13, 2680.

Potential role of TRPV4 in stretch-induced ghrelin secretion and obesity.
Hayakawa, S., Tanaka, T., Ogawa, R., Ito, S., Ueno, S., Koyama, H., … & Takiguchi, S.
(2022). International Journal of Endocrinology, 2022.

Physiological stretching induces a differential extracellular matrix gene expression response in acetabular labrum cells.
Huber, S., Günther, S., Cambria, E., Leunig, M., & Ferguson, S. J.
(2022). European Cells & Materials, 44, 90–100.

RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification.
Tachibana, N., Chijimatsu, R., Okada, H., Oichi, T., Taniguchi, Y., Maenohara, Y., … & Saito, T.
(2022). Science Advances, 8(33), eabn2138.

Cell disorientation by loss of SHH-dependent mechanosensation causes cyclopia.
Ohtsuka, D., Kida, N., Lee, S. W., Kawahira, N., & Morishita, Y.
(2022). Science Advances, 8(28), eabn2330.

Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells.
Kuromiya, K., Aoki, K., Ishibashi, K., Yotabun, M., Sekai, M., Tanimura, N., … & Fujita, Y.
(2022). Cell Reports, 40(2), 111078.

Myocyte culture with decellularized skeletal muscle sheet with observable interaction with extracellular matrix.
Nakada, S., Yamashita, Y., Akiba, S., Shima, T., & Arikawa-Hirasawa, E.
(2022). Research Square.

Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins.
Yuge, S., Nishiyama, K., Arima, Y., Hanada, Y., Oguri-Nakamura, E., Hanada, S., … & Fukuhara, S.
(2022). Nature Communications, 13(1), 1–25.

Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells.
Mochida, Y., Ochiai, K., Nagase, T., Nonomura, K., Akimoto, Y., Fukuhara, H., … & Nagase, M.
(2022). Scientific Reports, 12(1), 1–14.

Agitation of non-Brownian particles by active matrix of kinesin–microtubule motor proteins.
Meguriya, K., Yokoyama, T., Kobayashi, N., Yoshikawa, H. Y., Nakabayashi, S., & Kawamura, R.
(2022). ChemRxiv. Cambridge: Cambridge Open Engage.

Swelling-induced upregulation of miR-141-3p inhibits hepatocyte proliferation.
Bardeck, N., Paluschinski, M., Castoldi, M., Kordes, C., Görg, B., Stindt, J., … & Schöler, D.
(2022). JHEP Reports, 100440.

2021

TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure.
Uchida, T., Shimizu, S., Yamagishi, R., Tokuoka, S. M., Kita, Y., Sakata, R., … & Aihara, M.
(2021). PLOS ONE, 16(10), e0258911.

Homeostatic membrane tension constrains cancer cell dissemination by counteracting BAR protein assembly.
Tsujita, K., Satow, R., Asada, S., Nakamura, Y., Arnes, L., Sako, K., … & Itoh, T.
(2021). Nature Communications, 12(1), 1–14.

Effects of cyclic tensile strain and microgravity on the distribution of actin fiber and Fat1 cadherin in murine articular chondrocytes.
Hatakeyama, J., Nomura, M., Wakimoto, Y., Inoue, S., Li, C., Takamura, D., … & Moriyama, H.
(2021). Journal of Biomechanics, 110774.

A loss of nuclear–cytoskeletal interactions in vascular smooth muscle cell differentiation induced by a micro-grooved collagen substrate enabling the modeling of an in vivo cell arrangement.
Nagayama, K.
(2021). Bioengineering, 8(9), 124.

Piezo 1 is involved in intraocular pressure regulation.
Morozumi, W., Aoshima, K., Inagaki, S., Iwata, Y., Nakamura, S., Hara, H., & Shimazawa, M.
(2021). Journal of Pharmacological Sciences.

Daidzein induces bone morphogenetic protein-2 and runt-related transcription 2 on periodontal ligament cells after experimental tooth movement.
Sakurai, M., & Shimizu, M.
(2021). Orthodontic Waves, 79(4), 145–151.

Comparison of posterior root remnant cells and horn cells of the medial meniscus.
Zhang, X., Furumatsu, T., Okazaki, Y., Hiranaka, T., Xue, H., Kintaka, K., … & Ozaki, T.
(2021). Connective Tissue Research, 1–10.

Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers.
Huang, W., Matsui, T. S., Saito, T., Kuragano, M., Takahashi, M., Kawahara, T., … & Deguchi, S.
(2021). American Journal of Physiology-Cell Physiology.

Scleraxis upregulated by transforming growth factor-β1 signaling inhibits tension-induced osteoblast differentiation of periodontal ligament cells via ephrin A2.
Kawatsu, M., Takeshita, N., Takimoto, A., Yoshimoto, Y., Seiryu, M., Ito, A., … & Takano-Yamamoto, T.
(2021). Bone, 115969.

Influence of poly (N-isopropylacrylamide) (PIPAAm) graft density on properties of PIPAAm grafted poly (dimethylsiloxane) surfaces and their stability.
Akiyama, Y.
(2021). Heliyon, 7(3), e06520.

The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression.
Miyashita, Y., Tsukamoto, O., Matsuoka, K., Kamikubo, K., Kuramoto, Y., Fu, H. Y., … & Takashima, S.
(2021). The FASEB Journal, 35(4), e21495.

Mechanical stretch induces Ca²⁺ influx and extracellular release of PGE₂ through Piezo1 activation in trabecular meshwork cells.
Takatoshi, U., Shota, S., Reiko, Y., Tokuoka, S. M., Yoshihiro, K., Megumi, H., & Makoto, A.
(2021). Scientific Reports, 11(1).

Glucocorticoid counteracts cellular mechanoresponses by LINC01569-dependent glucocorticoid receptor–mediated mRNA decay.
Zhu, H., Li, J., Li, Y., Zheng, Z., Guan, H., Wang, H., … & Hu, D.
(2021). Science Advances, 7(9), eabd9923.

The stromal cell-derived factor-1 expression protected in periodontal tissues damage during occlusal traumatism.
Goto, K. T., Kajiya, H., Tsutsumi, T., Maeshiba, M., Tsuzuki, T., Ohgi, K., … & Okabe, K.
(2021). Journal of Hard Tissue Biology, 30(1), 63–68.

2020

Daidzein induces bone morphogenetic protein-2 and runt-related transcription 2 on periodontal ligament cells after experimental tooth movement.
Sakurai, M., & Shimizu, M.
(2020). Orthodontic Waves, 1–7.

Mechanical strain-mediated tenogenic differentiation of mesenchymal stromal cells is regulated through epithelial sodium channels.
Nam, H. Y., Murali, M. R., Ahmad, R. E., Pingguan-Murphy, B., Raghavendran, H. R. B., & Kamarul, T.
(2020). Stem Cells International, 2020.

Stretch in focus: 2D in-plane cell stretch systems for studies of cardiac mechano-signaling.
Schürmann, S., & Martinac, B.
(2020). Mechanobiology: Emerging Tools and Methods.

Conditioned media from mesenchymal stromal cells and periodontal ligament fibroblasts under cyclic stretch stimulation promote bone healing in mouse calvarial defects.
Ogisu, K., Fujio, M., Tsuchiya, S., Tsuboi, M., Qi, C., Toyama, N., … & Hibi, H.
(2020). Cytotherapy.

Enzyme-digested Colla Corii Asini (E’jiao) accelerates wound healing and prevents ultraviolet A-induced collagen synthesis decline and wrinkle formation in three-dimensional skin equivalents.
Xiao, L., Liao, F., Fan, Y., & Miwa, N.
(2020). Human Cell, 1–12.

Delayed tooth movement in Runx2+/− mice associated with mTORC2 in stretch-induced bone formation.
Aonuma, T., Tamamura, N., Fukunaga, T., Sakai, Y., Takeshita, N., Shigemi, S., … & Takano-Yamamoto, T.
(2020). Bone Reports, 100285.

L1CAM–ILK–YAP mechanotransduction drives proliferative activity of epithelial cells in middle ear cholesteatoma.
Yamamoto-Fukuda, T., Akiyama, N., & Kojima, H.
(2020). The American Journal of Pathology.

Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells.
Suzuki, M., Takahashi, N., Sobue, Y., Ohashi, Y., Kishimoto, K., Hattori, K., … & Kojima, T.
(2020). Scientific Reports, 10(1), 1–9.

Differences between the root and horn cells of the human medial meniscus from the osteoarthritic knee in cellular characteristics and responses to mechanical stress.
Okazaki, Y., Furumatsu, T., Kamatsuki, Y., Nishida, K., Nasu, Y., Nakahara, R., … & Ozaki, T.
(2020). Journal of Orthopaedic Science.

Mechanical stress regulates epithelial tissue integrity and stiffness through the FGFR/Erk2 signaling pathway during embryogenesis.
Kinoshita, N., Hashimoto, Y., Yasue, N., Suzuki, M., Cristea, I. M., & Ueno, N.
(2020). Cell Reports, 30(11), 3875–3888.

Functions of beta2‐adrenergic receptor in human periodontal ligament cells.
Hamano, S., Tomokiyo, A., Hasegawa, D., Yuda, A., Sugii, H., Yoshida, S., … & Maeda, H.
(2020). Journal of Cellular Biochemistry.

Two diverse hemodynamic forces, a mechanical stretch and a high wall shear stress, determine intracranial aneurysm formation.
Koseki, H., Miyata, H., Shimo, S., Ohno, N., Mifune, K., Shimano, K., … & Aoki, T.
(2020). Translational Stroke Research, 11(1), 80–92.

2019

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone.
Xuan, F., Yano, F., Mori, D., Chijimatsu, R., Maenohara, Y., Nakamoto, H., … & Hojo, H.
(2019). Arthritis Research & Therapy, 21(1), 1–11.

Impaired vascular smooth muscle cell force-generating capacity and phenotypic deregulation in Marfan Syndrome mice.
Nolasco, P., Fernandes, C. G., Ribeiro-Silva, J. C., Oliveira, P. V., Sacrini, M., de Brito, I. V., … & Laurindo, F. R. M.
(2019). Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 165587.

Genetic and mechanical regulation of intestinal smooth muscle development.
Huycke, T., Miller, B., Gill, H., Nerurkar, N., Sprinzak, D., Mahadevan, L., & Tabin, C.
(2019). Cell, 179(1), 90–105.

Evolution of bioengineered lung models: recent advances and challenges in tissue mimicry for studying the role of mechanical forces in cell biology.
Doryab, A., Tas, S., Taskin, M. B., Yang, L., Hilgendorff, A., Groll, J., … & Schmid, O.
(2019). Advanced Functional Materials, 1903114.

Depletion of glycosphingolipids induces excessive response of chondrocytes under mechanical stress.
Matsubara, S., Onodera, T., Maeda, E., Momma, D., Matsuoka, M., Homan, K., … & Iwasaki, N.
(2019). Journal of Biomechanics.

Bone and cartilage tissue engineering for growth modification using bone marrow derived mesenchymal stem cells (BMMSCs) on a resorbable electro-spun scaffold.
Souaid, R., Macari, A., Ghafari, J., & Sabban, M.
(2019). American University of Beirut, Department of Orthodontics and Dentofacial Orthopedics, Program and Division of Anatomy, Cell Biology and Physiology, American University of Beirut, Beirut, Lebanon.

Responses of bladder smooth muscle to the stretch go through extracellular signal‐regulated kinase (ERK)/p90 ribosomal S6 protein kinase (p90RSK)/nuclear factor‐κB (NF‐κB) pathway.
Li, Y., He, M., Lin, W., Xiang, Z., Huang, J., Xu, P., … & Wang, H.
(2019). Neurourology and Urodynamics, 38(6), 1504–1516.

Stretch in focus: 2D in-plane cell stretch systems for studies of cardiac mechano-signaling.
Friedrich, O., Merten, A. L., Schneidereit, D., Guo, Y., Schürmann, S., & Martinac, B.
(2019). Frontiers in Bioengineering and Biotechnology, 7.

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway.
Chang, S. H., Mori, D., Kobayashi, H., Mori, Y., Nakamoto, H., Okada, K., … & Kim-Kaneyama, J. R.
(2019). Nature Communications, 10(1), 1–13.

p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle.
Yamada, M., Iwata, M., Warabi, E., Oishi, H., Lira, V. A., & Okutsu, M.
(2019). The FASEB Journal, 33(7), 8022–8032.

L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2.
Takahashi, K., Hayashi, S., Miyajima, M., Omori, M., Wang, J., Kaihara, K., … & Naruse, K.
(2019). Cell Calcium, 79, 68–74.

Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: a systematic review of in vitro studies.
Li, M., Zhang, C., & Yang, Y.
(2019). Bone & Joint Research, 8(1), 19–31.

MT1‐MMP downregulation via the PI3K/Akt signaling pathway is required for the mechanical stretching‐inhibited invasion of bone‐marrow‐derived mesenchymal stem cells.
Fu, X., Halim, A., Tian, B., Luo, Q., & Song, G.
(2019). Journal of Cellular Physiology, 234(8), 14133–14144.

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas.
Shimizu, T., Osanai, Y., Tanaka, K. F., Thai, T. Q., Abe, M., Natsume, R., … & Ikenaka, K.
(2019). Journal of Neurochemistry, 150(2), 158–172.

R‐spondin 2 promotes osteoblastic differentiation of immature human periodontal ligament cells through the Wnt/β‐catenin signaling pathway.
Arima, M., Hasegawa, D., Yoshida, S., Mitarai, H., Tomokiyo, A., Hamano, S., … & Maeda, H.
(2019). Journal of Periodontal Research, 54(2), 143–153.

2018

TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons.
Katanosaka, K., Takatsu, S., Mizumura, K., Naruse, K., & Katanosaka, Y.
(2018). Scientific Reports, 8(1), 1–10.

Dynamic contact guidance of myoblasts by feature size and reversible switching of substrate topography: orchestration of cell shape, orientation, and nematic ordering of actin cytoskeletons.
Linke, P., Suzuki, R., Yamamoto, A., Nakahata, M., Kengaku, M., Fujiwara, T., … & Tanaka, M.
(2018). Langmuir, 35(23), 7538–7551.

MECHANOMEDICINE: applications of mechanobiology to medical sciences and next-generation medical technologies.
Naruse, K.
(2018). Journal of Smooth Muscle Research, 54, 83–90.

Poly (N-isopropylacrylamide) grafted PDMS substrate for controlling cell adhesion and detachment by dual stimulation of temperature and mechanical stress.
Akiyama, Y., Matsuyama, M., Yamato, M., Takeda, N., & Okano, T.
(2018). Biomacromolecules.

Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells.
Nakajima, T., Shibata, M., Nishio, M., Nagata, S., Alev, C., Sakurai, H., … & Ikeya, M.
(2018). Development, 145(16), dev165431.

Localization of leucine-rich repeat-containing G-protein-coupled receptor 5- and Ki67-positive periodontal cells expressing runt-related transcription factor 2 during tooth movement.
Hosomichi, J., Shibutani, N., Yamaguchi, H., Hatano, K., Kuma, Y., Suzuki, T., … & Ono, T.
(2018). Orthodontic Waves.

The time‐dependent variation of ATP release in mouse primary‐cultured urothelial cells is regulated by the clock gene.
Ihara, T., Mitsui, T., Nakamura, Y., Kanda, M., Tsuchiya, S., Kira, S., … & Shinozaki, Y.
(2018). Neurourology and Urodynamics.

Observation of calcium wave on physical stimulus for realizing cell tactile sensor.
Kawashima, H., Sajnani, U., Shimizu, M., & Hosoda, K.
(2018). Conference on Biomimetic and Biohybrid Systems (pp. 255–262). Springer, Cham.

Effects of daidzein on the production of type I collagen and matrix metalloproteinase 1 by stretched human periodontal ligament cells.
Yamaguchi, M., Nakayama, E., Shimizu, M., Kikuta, J., Horihata, S., & Kasai, K.
(2018). International Journal of Oral-Medical Sciences, 17(1), 27–32.

Cyclic stretching exacerbates tendinitis by enhancing NLRP3 inflammasome activity via F-actin depolymerization.
Chen, Q., Zhou, J., Zhang, B., Chen, Z., Luo, Q., & Song, G.
(2018). Inflammation, 1–13.

Intercondylar and central regions of complete discoid lateral meniscus have different cell and matrix organizations.
Furumatsu, T., Maehara, A., Okazaki, Y., & Ozaki, T.
(2018). Journal of Orthopaedic Science.

The oscillation of intracellular Ca²⁺ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium.
Ihara, T., Mitsui, T., Nakamura, Y., Kanda, M., Tsuchiya, S., Kira, S., … & Shigetomi, E.
(2018). Scientific Reports, 8(1), 5699.

Hypoxia triggers SENP1 (Sentrin-specific protease 1) modulation of KLF15 (Kruppel-like factor 15) and transcriptional regulation of Arg2 (arginase 2) in pulmonary endothelium.
Pandey, D., Nomura, Y., Rossberg, M. C., Hori, D., Bhatta, A., Keceli, G., … & Romer, L.
(2018). Arteriosclerosis, Thrombosis, and Vascular Biology.

2017

Contribution of plasma membrane lipid domains to red blood cell (re)shaping.
Léonard, C., Conrard, L., Guthmann, M., Pollet, H., Carquin, M., Vermylen, C., … & Tyteca, D.
(2017). Scientific Reports, 7(1), 4264.

Leucine supplementation after mechanical stimulation activates protein synthesis via L‐type amino acid transporter 1 in vitro.
Nakai, N., Kawano, F., Murakami, T., Nakata, K., & Higashida, K.
(2017). Journal of Cellular Biochemistry.

Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes.
Machida, T., Nishida, K., Nasu, Y., Nakahara, R., Ozawa, M., Harada, R., … & Ozaki, T.
(2017). Inflammation Research, 1–11.

Real-time imaging of mechanically and chemically induced ATP release in human lung fibroblasts.
Takahashi, K., Ito, S., Furuya, K., Asano, S., Sokabe, M., & Hasegawa, Y.
(2017). Respiratory Physiology & Neurobiology.

P2Y₆-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice.
Kira, S., Yoshiyama, M., Tsuchiya, S., Shigetomi, E., Miyamoto, T., Nakagomi, H., … & Koizumi, S.
(2017). Scientific Reports, 7(1), 771.

Hyaluronan inhibition of mechanical stress-induced protease expressions by human chondrocytes.
Ozawa, M., Nishida, K., Hashizume, K., Nakahara, R., Saito, T., Kanazawa, T., Harada, R., Machida, T., & Ozaki, T.
(2017). Abstracts accepted for publication: Cartilage, synovium and osteoimmunology.

2016

Endothelial cell‐derived endothelin‐1 is involved in abnormal scar formation by dermal fibroblasts through RhoA/Rho‐kinase pathway.
Kiya, K., Kubo, T., Kawai, K., Matsuzaki, S., Muramatsu, R., Maeda, D., … & Amano, G.
(2016). Experimental Dermatology.

Intravital imaging of mouse urothelium reveals activation of extracellular signal‐regulated kinase by stretch‐induced intravesical release of ATP.
Sano, T., Kobayashi, T., Negoro, H., Sengiku, A., Hiratsuka, T., Kamioka, Y., … & Matsuda, M.
(2016). Physiological Reports, 4(21), e13033.

An analysis of pathological activities of CCN proteins in joint disorders: mechanical stretch-mediated CCN2 expression in cultured meniscus cells.
Furumatsu, T., & Ozaki, T.
(2016). In CCN Proteins: Methods and Protocols (pp. 533–542). Springer.

In vitro experimental study for the determination of cellular characteristics of mesenchymal stem cells using a non-uniform deformation field.
Morita, Y., Sato, T., Watanabe, S., & Ju, Y.
(2016). In Experimental and Applied Mechanics, Volume 4 (pp. 131–137). Springer.

Evaluation of precise optimal cyclic strain for tenogenic differentiation of MSCs.
Morita, Y., Sato, T., Watanabe, S., & Ju, Y.
(2016). In Mechanics of Biological Systems and Materials, Volume 6 (pp. 149–155). Springer.

APPL1 promotes glucose uptake in response to mechanical stretch via the PKCζ–non-muscle myosin IIa pathway in C2C12 myotubes.
Saito, T., Okada, S., Shimoda, Y., Tagaya, Y., Osaki, A., Yamada, E., … & Mori, M.
(2016). Cellular Signalling, 28(11), 1694–1702.

Standardized scalp massage results in increased hair thickness by inducing stretching forces to dermal papilla cells in the subcutaneous tissue.
Koyama, T., Kobayashi, K., Hama, T., Murakami, K., & Ogawa, R.
(2016). Eplasty, 16.

Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase.
Nakagomi, H., Yoshiyama, M., Mochizuki, T., Miyamoto, T., Komatsu, R., Imura, Y., … & Araki, I.
(2016). Scientific Reports, 6, 29761.

Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia.
Mihara, H., Suzuki, N., Boudaka, A. A., Muhammad, J. S., Tominaga, M., Tabuchi, Y., & Sugiyama, T.
(2016). World Journal of Gastroenterology, 22(24), 5512.

Mechanical actuation systems for the phenotype commitment of stem cell-based tendon and ligament tissue substitutes.
Govoni, M., Muscari, C., Lovecchio, J., Guarnieri, C., & Giordano, E.
(2016). Stem Cell Reviews and Reports, 12(2), 189–201.

Uni-axial stretch induces actin stress fiber reorganization and activates c-Jun NH₂-terminal kinase via RhoA and Rho kinase in human bladder smooth muscle cells.
Kushida, N., Yamaguchi, O., Kawashima, Y., Akaihata, H., Hata, J., Ishibashi, K., … & Kojima, Y.
(2016). BMC Urology, 16(1), 9.

In situ time-series monitoring of collagen fibers produced by standing-cultured osteoblasts using a second-harmonic-generation microscope.
Hase, E., Matsubara, O., Minamikawa, T., Sato, K., & Yasui, T.
(2016). Applied Optics, 55(12), 3261–3267.

A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.
Zhang, Q., Matsui, H., Horiuchi, H., Liang, X., & Sasaki, K.
(2016). Biochemical and Biophysical Research Communications, 476(4), 438–444.

2015

Mechanical induction of interleukin‐11 regulates osteoblastic/cementoblastic differentiation of human periodontal ligament stem/progenitor cells. 
Monnouchi, S., Maeda, H., Yuda, A., Hamano, S., Wada, N., Tomokiyo, A., … & Akamine, A.
(2015). Journal of Periodontal Research, 50(2), 231-239.

Tissue inhibitor of metalloproteinase-2 suppresses collagen synthesis in cultured keloid fibroblasts.
Dohi, T., Miyake, K., Aoki, M., Ogawa, R., Akaishi, S., Shimada, T., … & Hyakusoku, H.
(2015). Plastic and Reconstructive Surgery Global Open, 3(9).

Rho guanine nucleotide exchange factors involved in cyclic‐stretch‐induced reorientation of vascular endothelial cells.
Abiko, H., Fujiwara, S., Ohashi, K., Hiatari, R., Mashiko, T., Sakamoto, N., … & Mizuno, K.
(2015). Journal of Cell Science, 128(9), 1683–1695.

Wnt5a induces collagen production by human periodontal ligament cells through TGFβ1‐mediated upregulation of periostin expression.
Hasegawa, D., Wada, N., Maeda, H., Yoshida, S., Mitarai, H., Tomokiyo, A., … & Akamine, A.
(2015). Journal of Cellular Physiology, 230(11), 2647–2660.

Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1β production and subsequent NF-κB activation.
Ozawa, M., Nishida, K., Yoshida, A., Saito, T., Harada, R., Machida, T., & Ozaki, T.
(2015). Inflammation Research, 64(3), 243–252.

Determination of precise optimal cyclic strain for tenogenic differentiation of mesenchymal stem cells using a non-uniform deformation field.
Morita, Y., et al.
(2015). Experimental Mechanics, 55(3), 635–640.

Force-dependent biotinylation of myosin IIA by α-catenin tagged with a promiscuous biotin ligase.
Ueda, S., et al.
(2015). PLOS ONE, 10(3).

Biomechanical strain induces elastin and collagen production in human pluripotent stem cell-derived vascular smooth muscle cells.
Wanjare, M., Agarwal, N., & Gerecht, S.
(2015). American Journal of Physiology-Cell Physiology, 309(4), C271–C281.

Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells.
Nakai, N., Kawano, F., & Nakata, K.
(2015). Molecular and Cellular Biochemistry.

Vascular endothelial cell membranes differentiate between stretch and shear stress through transitions in their lipid phases.
Yamamoto, K., & Ando, J.
(2015). American Journal of Physiology – Heart and Circulatory Physiology, 309(7), H1178–H1185.

Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line.
Yuda, A., et al.
(2015). Journal of Cellular Physiology, 230(1), 150–159.

The proliferation and tenogenic differentiation potential of bone marrow-derived mesenchymal stromal cells are influenced by specific uniaxial cyclic tensile loading conditions.
Nam, H. Y., et al.
(2015). Biomechanics and Modeling in Mechanobiology, 14(3), 649–663.

Hypertrophic scar contracture is mediated by the TRPC3 mechanical force transducer via NF-κB activation.
Ishise, H., et al.
(2015). Scientific Reports, 5.

Mechanical stretch on human skin equivalents increases the epidermal thickness and develops the basement membrane.
Tokuyama, E., et al.
(2015). PLOS ONE, 10(11), e0141989.

Possible effect of lysophosphatidic acid on cell proliferation and involvement of lysophosphatidic acid and its receptors in mechanical stretch‐induced mitogen‐activated protein kinase.
Kawashima, Y., et al.
(2015). International Journal of Urology, 22(8), 778–784.

2014

Angiopoietin-like protein 2 induced by mechanical stress accelerates degeneration and hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis.
Nakamura, T., et al.
(2014). PLOS ONE.

Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures.
Miyamoto, T., et al.
(2014). Journal of Biological Chemistry, 289(23), 16565–16575.

Mechanical forces induce odontoblastic differentiation of mesenchymal stem cells on three‐dimensional biomimetic scaffolds.
Miyashita, S., et al.
(2014). Journal of Tissue Engineering and Regenerative Medicine.

Real-time luminescence imaging of cellular ATP release.
Furuya, K., Sokabe, M., & Grygorczyk, R.
(2014). Methods, 66(2), 330–344.

Ca²⁺ influx and ATP release mediated by mechanical stretch in human lung fibroblasts.
Murata, N., et al.
(2014). Biochemical and Biophysical Research Communications, 453(1), 101–105.

Real-time imaging of ATP release induced by mechanical stretch in human airway smooth muscle cells.
Takahara, N., et al.
(2014). American Journal of Respiratory Cell and Molecular Biology, 51(6), 772–782.

Determination of tenogenic differentiation in human mesenchymal stem cells by terahertz waves for measurement of the optical property of cellular suspensions.
Morita, Y., et al.
(2014). Measurement Science and Technology, 25(6), 065703.

Mechanosensitive ATP release from hemichannels and Ca²⁺ influx through TRPC6 accelerate wound closure in keratinocytes.
Takada, H., Furuya, K., & Sokabe, M.
(2014). Journal of Cell Science, 127(19), 4159–4171.

Differences between protein expression and extracellular matrix state on uniaxial stretching for tenogenic differentiation.
Morita, Y., et al.
(2014). Journal of Mechanics in Medicine and Biology, 14(02), 1450025.

Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions.
Hirata, H., et al.
(2014). American Journal of Physiology-Cell Physiology, 306(6), C607–C620.

The expression of Fn14 via mechanical stress–activated JNK contributes to apoptosis induction in osteoblasts.
Matsui, H., et al.
(2014). Journal of Biological Chemistry.

2013

Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes.
Saito, T., et al.
(2013). Osteoarthritis and Cartilage, 21(1), 165–174.

Continuous cyclic stretch induces osteoblast alignment and formation of anisotropic collagen fiber matrix.
Matsugaki, A., Fujiwara, N., & Nakano, T.
(2013). Acta Biomaterialia, 7227–7235.

Mechanical stretch increases the proliferation while inhibiting the osteogenic differentiation in dental pulp stem cells.
Hata, M., et al.
(2013). Tissue Engineering Part A, 19(5–6).

Nicotine reduced MMP-9 expression in the primary porcine tenocytes exposed to cyclic stretch.
Hatta, T., et al.
(2013). Journal of Orthopaedic Research, 31(4), 645–650.

Imaging and characterization of stretch-induced ATP release from alveolar A549 cells.
Grygorczyk, R., Furuya, K., & Sokabe, M.
(2013). The Journal of Physiology, 591(5), 1195–1215.

Hyperocclusion up-regulates CCL3 expression in CCL2- and CCR2-deficient mice.
Tsutsumi, T., et al.
(2013). Journal of Dental Research, 92(1), 65–70.

Probing the microenvironmental conditions for induction of superficial zone protein expression.
Mhanna, R., et al.
(2013). Osteoarthritis and Cartilage, 21(12), 1924–1932.

In vitro experimental study for the determination of cellular axial strain threshold and preferential axial strain from cell orientation behavior in a non-uniform deformation field.
Morita, Y., et al.
(2013). Cell Biochemistry and Biophysics, 67(3), 1249–1259.

2012

Mechanical stretch enhances COL2A1 expression on chromatin by inducing SOX9 nuclear translocation in inner meniscus cells.
Kanazawa, T., et al.
(2012). Journal of Orthopaedic Research, 30(3), 468–474.

RhoA/ROCK, cytoskeletal dynamics and focal adhesion kinase are required for mechanical stretch-induced tenogenic differentiation of human mesenchymal stem cells.
Xu, B., Song, G., & Ju, Y.
(2012). Journal of Cellular Physiology, 227(6), 2722–2729.

The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel.
Nagai, Y., Yokoi, H., Kaihara, K., & Naruse, K.
(2012). Biomaterials, 33(4), 1044–1051.

FAK-ERK1/2 signaling pathway is necessary for proliferation of rat bone-marrow mesenchymal stem cells induced by cyclic stretching.
Yuan, L., et al.
(2012). Journal of Medical and Biological Engineering.

Live free or die: stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted.
Abbott, R. D., et al.
(2012). Biochemical and Biophysical Research Communications, 421(2), 361–366.

Dynamic changes of traction force at focal adhesions during macroscopic cell stretching using an elastic micropillar substrate: tensional homeostasis of aortic smooth muscle cells.
Nagayama, K., Adachi, A., & Matsumoto, T.
(2012). Journal of Biomechanical Science and Engineering, 7(2).

Mechanical stretch increases Smad3-dependent CCN2 expression in inner meniscus cells.
Furumatsu, T., Kanazawa, T., Miyake, Y., Kubota, S., Takigawa, M., & Ozaki, T.
(2012). Journal of Orthopaedic Research, 30(11), 1738–1745.

Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells.
Miyake, Y., et al.
(2012). Biochemical and Biophysical Research Communications, 409(2), 247–252.

Dependence of cyclic stretch-induced stress fiber reorientation on stretch waveform.
Tondon, A., Hsu, H. J., & Kaunas, R.
(2012). Journal of Biomechanics, 45(5), 728–735.

Role of nesprin-1 in nuclear deformation in endothelial cells under static and uniaxial stretching conditions.
Anno, T., Sakamoto, N., & Sato, M.
(2012). Biochemical and Biophysical Research Communications, 424(1), 94–99.

Latent transforming growth factor-β binding protein 2 negatively regulates coalescence of oxytalan fibers induced by stretching stress.
Tsuruga, E., et al.
(2012). Connective Tissue Research, 53(6), 521–527.

Role of paxillin in the early phase of orientation of vascular endothelial cells exposed to cyclic stretching.
Huang, W., et al.
(2012). Biochemical and Biophysical Research Communications, 418(4), 708–713.

Strain waveform dependence of stress fiber reorientation in cyclically stretched osteoblastic cells: effects of viscoelastic compression of stress fibers.
Nagayama, K., Kimura, Y., Makino, N., & Matsumoto, T.
(2012). American Journal of Physiology – Cell Physiology.

Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels.
Oishi, S., et al.
(2012). Journal of Pharmacological Sciences.

2011

Development of a biochip with serially connected pneumatic balloons for cell-stretching culture.
Shimizu, K., Shunori, A., Morimoto, K., Hashida, M., & Konishi, S.
(2011). Sensors and Actuators B: Chemical, 156(1), 486–493.

Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143.
Miyasaka, K. Y., et al.
(2011). Mechanisms of Development, 128(1–2), 18–28.

Akt-mediated mechanotransduction in murine fibroblasts during hypertrophic scar formation.
Paterno, J., et al.
(2011). Wound Repair and Regeneration, 19(1), 49–58.

Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch.
Xu, B., Song, G., & Ju, Y.
(2011). Connective Tissue Research, 52(5), 373–379.

Cyclic stretch induces upregulation of endothelin-1 with keratinocytes in vitro: possible role in mechanical stress-induced hyperpigmentation.
Kurita, M., et al.
(2011). Biochemical and Biophysical Research Communications, 409(1), 103–107.

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells.
Tetsunaga, T., et al.
(2011). Osteoarthritis and Cartilage, 19(2), 222–232.

Gene regulation of extracellular matrix remodeling in human bone marrow stem cell-seeded tissue-engineered grafts.
Emani, S., & Emani, S. M.
(2011). Tissue Engineering Part A, 17(19–20).

Essential role for microtubule dynamics in cyclic stretch-induced cell alignment in human airway smooth muscle cells.
Ito, S., et al.
(2011). American Journal of Respiratory and Critical Care Medicine Meeting Abstracts.

Stretch stimuli increase fibulin-5/EMILIN-1 complex on oxytalan fibers in human periodontal ligament cells.
Nakashima, K., et al.
(2011). Orthodontic Waves, 70(1), 15–20.

The roles of angiotensin II in stretched periodontal ligament cells.
Monnouchi, S., et al.
(2011). Journal of Dental Research, 90(2), 181–185.

TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts.
Fukuno, N., et al.
(2011). Biochemical and Biophysical Research Communications, 408(2), 202–207.

Hyperocclusion stimulates osteoclastogenesis via CCL2 expression.
Goto, K. T., et al.
(2011). Journal of Dental Research, 90(6), 793–798.

Role of intercellular junctions in redistribution of focal adhesions and orientation of vascular endothelial cells exposed to cyclic stretching.
Huang, W., et al.
(2011). Cellular and Molecular Bioengineering, 4(3), 368–378.

Cyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3.
Zhu, J. H., et al.
(2011). American Journal of Physiology – Heart and Circulatory Physiology, 300, H1770–H1780.

Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping.
Taguchi, K., Ishiuchi, T., & Takeichi, M.
(2011). Journal of Cell Biology, 194(4), 643–656.

Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling.
Kim-Kaneyama, J. R., et al.
(2011). Journal of Molecular and Cellular Cardiology, 50(1), 77–86.

Combined stimulation with cyclic stretching and hypoxia increases production of matrix metalloproteinase-9 and cytokines by macrophages.
Otya, K., et al.
(2011). Biochemical and Biophysical Research Communications, 412(4), 678–682.

Heterogeneous response of traction force at focal adhesions of vascular smooth muscle cells subjected to macroscopic stretch on a micropillar substrate.
Nagayama, K., Adachi, A., & Matsumoto, T.
(2011). Journal of Biomechanics, 44(15), 2699–2705.

Role of heme oxygenase-1 in inflammatory response induced by mechanical stretch in synovial cells.
Takao, M., et al.
(2011). Inflammation Research, 60(9), 861–867.

Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes.
Mihara, H., et al.
(2011). The Journal of Physiology, 589(14), 3471–3482.

Angiotensin II induces microtubule reorganization mediated by a deacetylase SIRT2 in endothelial cells.
Hashimoto-Komatsu, A., et al.
(2011). Hypertension Research, 34, 949–956.

Caveolae respond to cell stretch and contribute to stretch-induced signaling.
Gervasio, O. L., et al.
(2011). Journal of Cell Science, 124, 3581–3590.

Mechanical loading increased BMP-2 expression which promoted osteogenic differentiation of tendon-derived stem cells.
Rui, Y. F., et al.
(2011). Journal of Orthopaedic Research, 29(3), 390–396.

The kinase Pyk2 is involved in renal fibrosis by means of mechanical stretch–induced growth factor expression in renal tubules.
Sonomura, K., et al.
(2011). Kidney International, 81, 449–457.

2010

Stretch-induced stress fiber remodeling and the activations of JNK and ERK depend on mechanical strain rate, but not FAK.
Hsu, H. J., et al.
(2010). PLOS ONE.

Intracellular memory of stress fiber orientation: focal adhesions store it and microtubules erase it during disassembly–reassembly process of stress fibers.
Yang, Y. F., Nagayama, K., & Matsumoto, T.
(2010). In IFMBE Proceedings.

Actin cytoskeleton regulates mechanical stretch-activated Ca²⁺ influx in human lung microvascular endothelial cells.
Ito, S., et al.
(2010). American Journal of Respiratory Cell and Molecular Biology, 43(1), 26–34.

TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons.
Shibasaki, K., et al.
(2010). Journal of Neuroscience, 30(13), 4601–4612.

Mechanical stretch enhances IL-8 production via p38 activation in human pulmonary microvascular endothelial cells.
Ito, S., et al.
(2010). American Journal of Respiratory and Critical Care Medicine Meeting Abstracts.

Mechanical stretch activates signaling events for protein translation initiation and elongation in C2C12 myoblasts.
Nakai, N., et al.
(2010). Molecules and Cells, 30(6), 513–518.

ERK1/2 mediates mechanical stretch-induced proliferation of bone marrow-derived mesenchymal stem cells.
Song, G., et al.
(2010). In 6th World Congress of Biomechanics (WCB 2010).

Distinct mechanosensitive Ca²⁺ influx mechanisms in human primary synovial fibroblasts.
Sakamoto, Y., et al.
(2010). Journal of Orthopaedic Research, 28(7), 859–864.

High-glucose condition reduces cardioprotective effects of insulin against mechanical stress-induced cell injury.
Teshima, Y., et al.
(2010). Life Sciences, 87(5–6), 154–161.

Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition.
Nishida, M., et al.
(2010). Journal of Biological Chemistry, 285, 13244–13253.

Differential induction of collagens by mechanical stress in human periodontal ligament cells.
Nemoto, T., et al.
(2010). Archives of Oral Biology, 55(12), 981–987.

2009

The TRPV4 cation channel mediates stretch-evoked Ca²⁺ influx and ATP release in primary urothelial cell cultures.
Mochizuki, T., et al.
(2009). Journal of Biological Chemistry, 284(32), 21257–21264.

Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells.
Iwaki, M., et al.
(2009). Biochemical and Biophysical Research Communications, 389(3), 531–536.

Stretching modulates oxytalan fibers in human periodontal ligament cells.
Tsuruga, E., et al.
(2009). Journal of Periodontal Research, 44(2), 170–174.

Stretching stimulates fibulin-5 expression and controls microfibril bundles in human periodontal ligament cells.
Nakashima, K., et al.
(2009). Journal of Periodontal Research, 44(5), 622–627.

Temporal effects of cyclic stretching on distribution and gene expression of integrin and cytoskeleton by ligament fibroblasts in vitro.
Kaneko, D., et al.
(2009). Connective Tissue Research, 50(4), 263–269.

Application of mechanical strain to chondrocytes in 3D culture.
Zenobi-Wong, M., Franco-Obregon, A., & Vörös, J.
(2009). Interface Oral Health Science.

Mechanical stress induces the activation of TAK1 and its downstream pathways in pre-osteoblastic cells.
Fukuno, N., et al.
(2009). In Micro-NanoMechatronics and Human Science, 2009.

Mechanical stress modulates bone remodeling signals.
Matsui, H., et al.
(2009). In Interface Oral Health Science 2009.

Uniaxial cyclic stretch increases glucose uptake into C2C12 myotubes through a signaling pathway independent of insulin-like growth factor I.
Iwata, M., et al.
(2009). Hormone and Metabolic Research, 41, 16–22.

Characterization of contraction-inducible CXC chemokines and their roles in C2C12 myocytes.
Nedachi, T., et al.
(2009). American Journal of Physiology – Endocrinology and Metabolism, 297, E866–E878.

Mechanical stretch stimulates integrin αVβ3-mediated collagen expression in human anterior cruciate ligament cells.
Tetsunaga, T., et al.
(2009). Journal of Biomechanics, 42(13), 2097–2103.

Effects of relaxin on collagen type I released by stretched human periodontal ligament cells.
Takano, M., et al.
(2009). Orthodontics & Craniofacial Research, 12(4), 282–288.

Regulation of endothelin-1-induced interleukin-6 production by Ca²⁺ influx in human airway smooth muscle cells.
Iwata, S., et al.
(2009). European Journal of Pharmacology, 605(1–3), 15–22.

Effects of three-dimensional culture and cyclic stretch stimulation on expression of contractile proteins in freshly isolated rat aortic smooth muscle cells.
Nagayama, K., Morishima, N., & Matsumoto, T.
(2009). Journal of Biomechanical Science and Engineering, 4(2).

Passage-affected competitive regulation of osteoprotegerin synthesis and receptor activator of nuclear factor-κB ligand mRNA expression in normal human osteoblasts stimulated by application of cyclic tensile strain.
Kusumi, A., et al.
(2009). Journal of Bone and Mineral Metabolism, 27(6), 653–662.

The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells.
Ohmine, T., et al.
(2009). Hypertension Research, 32, 690–699.

Early postoperative oral intake accelerates upper gastrointestinal anastomotic healing in the rat model.
Sosuke, T., et al.
(2009). Journal of Surgical Research, 169(2), 202–208.

2008

A novel Ca²⁺ influx pathway activated by mechanical stretch in human airway smooth muscle cells.
Ito, S., et al.
(2008). American Journal of Respiratory Cell and Molecular Biology, 38(4), 407–413.

Analysis of cyclic-stretching responses using cell-adhesion-patterned cells.
Katanosaka, Y., et al.
(2008). Journal of Biotechnology, 133(1), 82–89.

Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells.
Arai, K., et al.
(2008). Cell Structure and Function, 33, 203–210.

Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor β.
Shimizu, N., et al.
(2008). Journal of Applied Physiology, 104, 766–772.

Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel.
Hirano, Y., et al.
(2008). Journal of Biotechnology, 133(2), 245–252.

Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation.
Chiu, Y. J., McBeath, E, & Fujiwara, K.
(2008). Journal of Cell Biology, 182(4), 753–763.

Mechanical forces facilitate actin polymerization at focal adhesions in zyxin-dependent manner.
Hirata, H., Tatsumi, H., & Sokabe, M.
(2008). Journal of Cell Science, 121(17), 2795–2804.

Regulation of cyclic longitudinal mechanical stretch on proliferation of human bone marrow mesenchymal stem cells.
Song, G., et al.
(2008). MCB, 90(1), 1–10.

Application of elastic salmon collagen gel to uniaxial stretching culture of human umbilical vein endothelial cells.
Kanayama, T., et al.
(2008). Journal of Bioscience and Bioengineering, 105(5), 554–557.

Loading of mechanical stress to osteoblasts may induce cytokine cross talks between osteoblasts and monocytes/macrophages in a JNK/p38-dependent manner.
Matsui, H., et al.
(2008). In Micro-NanoMechatronics and Human Science, 2008.

Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration.
Nishida, T., et al.
(2008). Biorheology, 45(3–4), 289–299.

Remodeling of endothelial cell nucleus exposed to three different mechanical stimuli.
Ohashi, T., et al.
(2008). Journal of Biomechanical Science and Engineering, 3(2).

2007

The influence of serial passage on cyclic tensile strain-induced osteoprotegerin synthesis from normal human osteoblasts in vitro.
Kusumi, A., et al.
(2007). Hirosaki Medical Journal, 59(Suppl.), S172–S187.

Uniaxial cyclic stretch-stimulated glucose transport is mediated by a Ca²⁺-dependent mechanism in cultured skeletal muscle cells.
Iwata, M., et al.
(2007). Pathobiology, 74, 159–168.

Novel mechanisms of valsartan on the treatment of acute myocardial infarction through inhibition of the antiadhesion molecule periostin.
Iekushi, K., et al.
(2007). Hypertension, 49(6), 1409–1414.

Rac1 activity is required for cardiac myocyte alignment in response to mechanical stress.
Yamane, M., et al.
(2007). Biochemical and Biophysical Research Communications, 353(4), 1023–1027.

Down-regulation of ERK but not MEK phosphorylation in cultured endothelial cells by repeated changes in cyclic stretch.
Shi, F., et al.
(2007). Cardiovascular Research, 73, 813–822.

The magnitude and duration of cyclic stretch affect JNK and p38 activation in MC3T3-E1 pre-osteoblastic cells.
Matsui, H., et al.
(2007). In Micro-NanoMechatronics and Human Science, 2007.

Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation.
Sasaki, K., et al.
(2007). Journal of Biomedical Materials Research Part B: Applied Biomaterials, 80(2), 491–498.

2006

N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes.
Matsuda, T., et al.
(2006). Journal of Molecular and Cellular Cardiology, 40(4), 495–502.

Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs.
Takeda, H., et al.
(2006). Life Sciences, 79(3), 233–239.

Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.
Ito, S., et al.
(2006). European Journal of Pharmacology, 552(1–3), 135–142.

Involvement of STAT3 in bladder smooth muscle hypertrophy following bladder outlet obstruction.
Fujita, O., et al.
(2006). Acta Medica Okayama, 60(6), 299–309.

The effect of cyclic uniaxial stretch on E-selectin expression in HUVEC cells.
Suchodolski, K., et al.
(2006). American Society of Anesthesiologists Abstracts.

2005

Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch.
Sasamoto, A., et al.
(2005). American Journal of Physiology-Cell Physiology, 288, C1012–C1022.

Fabrication of reconfigurable protein matrices by cracking.
Zhu, X., et al.
(2005). Nature Materials, 4, 403–406.

Uni-axial stretching regulates intracellular localization of Hic-5 expressed in smooth-muscle cells in vivo.
Kim-Kaneyama, J. R., et al.
(2005). Life Sciences, 76(24), 2817–2825.

Stretch-induced cell proliferation is mediated by FAK-MAPK pathway.
Wang, J. G., et al.
(2005). Life Sciences, 76(24), 2817–2825.

Involvement of reactive oxygen species in cyclic stretch-induced NF-κB activation in human fibroblast cells.
Amma, H., et al.
(2005). British Journal of Pharmacology, 145(3), 364–373.

Characteristics of subepithelial fibroblasts as a mechano-sensor in the intestine: cell-shape-dependent ATP release and P2Y1 signaling.
Furuya, K., Sokabe, M., & Furuya, S.
(2005). Journal of Cell Science, 118(15), 3289–3304.

2004

N-cadherin-mediated cell adhesion determines the plasticity for cell alignment in response to mechanical stretch in cultured cardiomyocytes.
Matsuda, T., et al.
(2004). Biochemical and Biophysical Research Communications, 326(1), 228–232.

Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament.
Iwasaki, K., et al.
(2004). Calcified Tissue International, 74(5), 448–457.

Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes.
Yano, S., et al.
(2004). Journal of Investigative Dermatology, 122, 783–790.

2003

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts.
Danciu, T. E., et al.
(2003). FEBS Letters, 536(1–3), 193–197.

A novel mechanism of myocyte degeneration involving the Ca²⁺-permeable growth factor–regulated channel.
Iwata, Y., et al.
(2003). Journal of Cell Biology, 161(5), 957–967.

Stretch-induced IL-6 secretion from endothelial cells requires NF-κB activation.
Kobayashi, S., et al.
(2003). Biochemical and Biophysical Research Communications, 308(2), 306–312.

2002

Uni-axial cyclic stretch induces the activation of transcription factor nuclear factor kappaB in human fibroblast cells.
Inoh, H., et al.
(2002). The FASEB Journal, 16(3), 405–407.

2001

Uniaxial cyclic stretch induces focal adhesion kinase (FAK) tyrosine phosphorylation followed by mitogen-activated protein kinase (MAPK) activation.
Wang, J. G., et al.
(2001). Biochemical and Biophysical Research Communications, 288(2), 356–361.

Stretch-activated (SA) channel mediates superoxide production in HUVECs.
Aikawa, K., et al.
(2001). Life Sciences, 69(15), 1717–1724.

Protamine augments stretch-induced calcium increase in vascular endothelium.
Murase, K., et al.
(2001). British Journal of Pharmacology, 134(7), 1403–1410.

2000

Stretch-induced morphological changes of human endothelial cells depend on the intracellular level of Ca²⁺ rather than of cAMP.
Yamada, T., Naruse, K., & Sokabe, M.
(2000). Life Sciences, 67(21), 2605–2613.

1999

Molecular identification of a eukaryotic, stretch-activated nonselective cation channel.
Kanzaki, M., et al.
(1999). Science, 285, 882–886.

Orientation change of cardiocytes induced by cyclic stretch stimulation: time dependency and involvement of protein kinases.
Kada, K., et al.
(1999). Journal of Molecular and Cellular Cardiology, 31(1), 247–259.

Activation of pp60src is critical for stretch-induced orienting response in fibroblasts.
Sai, X., Naruse, K., & Sokabe, M.
(1999). Journal of Cell Science, 112, 1365–1373.

1998

Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch.
Naruse, K., Yamada, T., & Sokabe, M.
(1998). American Journal of Physiology – Heart and Circulatory Physiology, 274, H1532–H1538.

Pp125FAK is required for stretch dependent morphological response of endothelial cells.
Naruse, K., et al.
(1998). Oncogene, 17(4), 455–463.

Up regulation of COX2 expression by uni-axial cyclic stretch in human lung fibroblast cells.
Kato, T., et al.
(1998). Biochemical and Biophysical Research Communications, 244(3), 615–619.

Uni-axial cyclic stretch induces c-src activation and translocation in human endothelial cells via SA channel activation.
Naruse, K., Sai, X., Yokoyama, N., & Sokabe, M.
(1998). FEBS Letters, 441(1), 111–115.

1997

Up-regulation of integrin β3 expression by cyclic stretch in human umbilical endothelial cells.
Suzuki, M., et al.
(1997). Biochemical and Biophysical Research Communications, 239(2), 372–376.

Mechanotransduction and intracellular signaling mechanisms of stretch-induced remodeling in endothelial cells.
Sokabe, M., et al.
(1997). Heart and Vessels, Suppl 12, 191–193.